On total domination vertex critical graphs of high connectivity

AbstractA graph is called γ-critical if the removal of any vertex from the graph decreases the domination number, while a graph with no isolated vertex is γt-critical if the removal of any vertex that is not adjacent to a vertex of degree 1 decreases the total domination number. A γt-critical graph that has total domination number k, is called k-γt-critical. In this paper, we introduce a class of k-γt-critical graphs of high connectivity for each integer k≥3. In particular, we provide a partial answer to the question “Which graphs are γ-critical and γt-critical or one but not the other?” posed in a recent work [W. Goddard, T.W. Haynes, M.A. Henning, L.C. van der Merwe, The diameter of total domination vertex critical graphs, Discrete Math. 286 (2004) 255–261]

Evolution of Preprofessional Pharmacy Curricula

Objectives. To examine changes in preprofessional pharmacy curricular requirements and trends, and determine rationales for and implications of modifications. Methods. Prerequisite curricular requirements compiled between 2006 and 2011 from all doctor of pharmacy (PharmD) programs approved by the Accreditation Council of Pharmacy Education were reviewed to ascertain trends over the past 5 years. An online survey was conducted of 20 programs that required either 3 years of prerequisite courses or a bachelor’s degree, and a random sample of 20 programs that required 2 years of prerequisites. Standardized telephone interviews were then conducted with representatives of 9 programs. Results. In 2006, 4 programs required 3 years of prerequisite courses and none required a bachelor’s degree; by 2011, these increased to 18 programs and 7 programs, respectively. Of 40 programs surveyed, responses were received from 28 (70%), 9 (32%) of which reported having increased the number of prerequisite courses since 2006. Reasons given for changes included desire to raise the level of academic achievement of students entering the PharmD program, desire to increase incoming student maturity, and desire to add clinical sciences and experiential coursework to the pharmacy curriculum. Some colleges and schools experienced a temporary decrease in applicants. Conclusions. The preprofessional curriculum continues to evolve, with many programs increasing the number of course prerequisites. The implications of increasing prerequisites were variable and included a perceived increase in maturity and quality of applicants and, for some schools, a temporary decrease in the number of applicants

Effects of chronic methylphenidate on cocaine self-administration under a progressive-ratio schedule of reinforcement in rhesus monkeys

ABSTRACT It has been hypothesized that drugs that serve as substrates for dopamine (DA) and norepinephrine (NE) transporters may be more suitable medications for cocaine dependence than drugs that inhibit DA and NE uptake by binding to transporters. Previous studies have shown that the DA/NE releaser d-amphetamine can decrease cocaine self-administration in preclinical and clinical studies. The present study examined the effects of methylphenidate (MPD), a DA uptake inhibitor, for its ability to decrease cocaine self-administration under conditions designed to reflect clinically relevant regimens of cocaine exposure and pharmacotherapy. Each morning, rhesus monkeys pressed a lever to receive food pellets under a fixed-ratio 50 schedule of reinforcement; cocaine was self-administered under a progressiveratio schedule of reinforcement in the evening. After cocaine (0.003-0.56 mg/kg per injection, i.v.) dose-response curves were determined, self-administration sessions were suspended and MPD (0.003-0.0056 mg/kg per hr, i.v. or 1.0-9.0 mg/kg p.o., b.i.d.) was administered for several weeks. A cocaine self-administration session was conducted every 7 days. When a MPD dose was reached that either persistently decreased cocaine self-administration or produced disruptive effects, the cocaine dose-effect curve was re-determined. In most cases, MPD treatment either produced behaviorally disruptive effects or increased cocaine selfadministration; it took several weeks for these effects to dissipate. These data are consistent with the largely negative results of clinical trials with MPD. In contrast to the positive effects with the monoamine releaser d-amphetamine under identical conditions, these results do not support use of monoamine uptake inhibitors like MPD as a medication for cocaine dependence

Nanofilters for Optical Nanocircuits

We theoretically and numerically study the design of optical 'lumped' nanofiltering devices in the framework of our recently proposed paradigm for optical nanocircuits. In particular, we present the design of basic filtering elements, such as low-pass, band-pass, stop-band and high-pass 'lumped' nanofilters, for use in optical nanocircuits together with more complex designs, such as multi-zero or multi-pole nanofilters, to work at THz, infrared and optical frequencies. Following the nanocircuit theory, we show how it is possible to design such complex frequency responses by simple rules, similar to RF circuit design, and we compare the frequency response of these optical nanofilters with classic filters in RF circuits. These results may provide a theoretical foundation for fabricating nanofilters in optical lumped nanocircuit devices.Comment: 34 pages, 14 figure

UC Cooperative Extension works with fire safe councils to reduce wildfires

In Plumas, Butte and Yuba counties, UC Cooperative Extension advisors have collaborated with fire safe councils to mitigate the risk of wildfire in local communities. They have determined the educational needs within the communities, obtained grant funding and worked collaboratively with the councils to deliver education and applied research programs that have helped homeowners and landowners take action to reduce their vulnerability to the risk of wildfires. Home structures have been modified to improve their fire resistance, fuel reduction programs have been adopted by local communities and maintained, communities have been mapped for evacuation plans and fuel breaks have been constructed on private and public forestland. Several wildfires, including the Marysville fire in 2006 and the Yuba fire in 2009, were slowed or stopped because of measures taken, showing the value of investment in pre-fire planning and actions

Discriminative and reinforcing effects of brotizolam in rhesus monkeys

The reinforcing and discriminative stimulus effects of brotizolam, a benzodiazepine-hypnotic, were evaluated in rhesus monkeys. In one experiment, separate groups of monkeys ( N =3/group) were trained to discriminate pentobarbital (10 mg/kg, IG) or d -amphetamine (0.56–1.0 mg/kg, IG) from saline, in a discrete-trials avoidance/escape paradigm. Pentobarbital (5.6–10 mg/kg), diazepam (1.0–1.7 mg/kg), and brotizolam (0.3–1.7 mg/kg) resulted in 100% drug-lever responding in all three pentobarbital-trained monkeys. In d -amphetamine-trained monkeys brotizolam administration resulted only in saline-lever responding. In another experiment, monkeys were surgically prepared with indwelling intravenous catheters and lever pressing resulted in an injection of 0.1 mg/kg/injection sodium methohexital under a fixed-ratio 10 (FR 10) schedule. Pentobarbital (0.01–0.3 mg/kg/injection) and diazepam (0.003–0.10 mg/kg/injection) maintained responding above saline control levels when substituted for methohexital. Brotizolam (0.001–0.01 mg/kg/injection) resulted in more injections received compared to saline, but fewer injections compared to pentobarbital or diazepam. Thus, results from the present experiment suggest that brotizolam would have pentobarbital-like subjective effects. However, the abuse liability of brotizolam may be lower than that for diazepam.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46334/1/213_2005_Article_BF02244198.pd

Super-Earths: A New Class of Planetary Bodies

Super-Earths, a class of planetary bodies with masses ranging from a few Earth-masses to slightly smaller than Uranus, have recently found a special place in the exoplanetary science. Being slightly larger than a typical terrestrial planet, super-Earths may have physical and dynamical characteristics similar to those of Earth whereas unlike terrestrial planets, they are relatively easier to detect. Because of their sizes, super-Earths can maintain moderate atmospheres and possibly dynamic interiors with plate tectonics. They also seem to be more common around low-mass stars where the habitable zone is in closer distances. This article presents a review of the current state of research on super-Earths, and discusses the models of the formation, dynamical evolution, and possible habitability of these objects. Given the recent advances in detection techniques, the detectability of super-Earths is also discussed, and a review of the prospects of their detection in the habitable zones of low-mass stars is presented.Comment: A (non-technical) review of the literature on the current state ofresearch on super-Earths. The topics include observation, formation, dynamical evolution, habitability, composition, interior dynamics, magnetic field, atmosphere, and propsect of detection. The article has 44 pages, 27 figures, and 203 references. It has been accepted for publication in the journal Contemporary Physics (2011